Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation
Melissa J Buskes, Katherine L Harvey, Benjamin J Richards, Robabeh Kalhor, Rebecca M Christoff, Chamodi K Gardhi, Dene R Littler, Elliott D Cope, Boris Prinz, Greta E Weiss, Nathan J O'Brien, Brendan S Crabb, Leslie W Deady, Paul R Gilson, Belinda M Abbott
Organic & Biomolecular Chemistry | ROYAL SOC CHEMISTRY | Published : 2016
M.B. acknowledges the support of the CRC for Biomarker Translation, funded by the Australian Government, in the provision of her postgraduate scholarship. K.H. is the recipient of an Australian Postgraduate Award from the University of Melbourne, Australia. The authors also wish to acknowledge the undergraduate chemistry students who contributed to this project, Banin Rasouli, Dylan Smith, Nikolaj Villadsen, Kristofer Cupic and Bethany Davey (Department of Chemistry and Physics, La Trobe Institute for Molecular Science, La Trobe University). We also acknowledge the contribution made by Dr Jason Dang (Monash Institute of Pharmaceutical Sciences, Monash University) for HRMS analysis and the MRC PPU International Centre for Kinase Profiling (University of Dundee, United Kingdom) for the human kinase screening. This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia. The authors gratefully acknowledge the contribution of the Victorian Operational Infrastructure Support Program, Australia received by the Burnet Institute and Monash Micro Imaging.