Journal article

The dynamic relationship between cerebellar Purkinje cell simple spikes and the spikelet number of complex spikes

Amelia Burroughs, Andrew K Wise, Jianqiang Xiao, Conor Houghton, Tianyu Tang, Colleen Y Suh, Eric J Lang, Richard Apps, Nadia L Cerminara



KEY POINTS: Purkinje cells are the sole output of the cerebellar cortex and fire two distinct types of action potential: simple spikes and complex spikes. Previous studies have mainly considered complex spikes as unitary events, even though the waveform is composed of varying numbers of spikelets. The extent to which differences in spikelet number affect simple spike activity (and vice versa) remains unclear. We found that complex spikes with greater numbers of spikelets are preceded by higher simple spike firing rates but, following the complex spike, simple spikes are reduced in a manner that is graded with spikelet number. This dynamic interaction has important implications for cerebellar..

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University of Melbourne Researchers