Journal article
Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion
RMW Kremers, RJ Wagenvoord, HB de Laat, P Monagle, HC Hemker, V Ignjatovic
Thrombosis and Haemostasis | SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN | Published : 2016
DOI: 10.1160/TH15-09-0716
Abstract
Thrombin generation (TG) is decreased in children. TG is determined by two underlying processes: the conversion of prothrombin to thrombin and the inactivation of thrombin. Therefore, lower TG capacity in children can either be caused by a reduction of prothrombin conversion, an increase of thrombin inactivation, or both. In 36 children and 8 adults, TG and the factors that determine thrombin inactivation (antithrombin, α2Macroglobulin (α2M) and fibrinogen) were measured. Prothrombin conversion, thrombin inhibitor complex formation, and the overall thrombin decay capacity were determined. In silico modelling was performed to determine the contribution prothrombin conversion and thrombin inac..
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