Journal article

Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Andrew S Brown, Chao Yang, Ka Yee Fung, Annabell Bachem, Dorothee Bourges, Sammy Bedoui, Elizabeth L Hartland, Ian R van Driel



Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular replication of L. pneumophila, however the contributions of other immune cell types to bacterial killing during infection are unclear. Here, we used recently described methods to characterise the major inflammatory cells in lung after acute respiratory infection of mice with L. pneumophila. We observed that the numbers of alveolar macrophages rapidly decreased after infection coincident with a rapid infiltration of the lung by monocyte-derived cells (MC), which, together with neutrophils, became the dominant inflammatory cells associated with ..

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Funding Acknowledgements

This work was supported by awards from the Australian National Health and Medical Research Council and the University of Melbourne. ASB was supported by an Australian Postgraduate Award from the Australian Federal Government and a scholarship from the Bio21 Molecular Science and Biotechnology Institute. CY is supported by a scholarship from the University of Melbourne. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.