Journal article
Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy
M Krause, J Keller, B Beil, I van Driel, J Zustin, F Barvencik, T Schinke, M Amling
Osteoporosis International | SPRINGER LONDON LTD | Published : 2015
Abstract
Summary: We demonstrate histological evidence for hyperparathyroidism in patients with gastrectomy. This is, at least in part, explained by impaired calcium absorption, resulting in mineralization defects and secondary hyperparathyroidism. Additionally, we demonstrate improved bone mineralization in patients with gastrectomy after gluconate therapy and showed the effectiveness of calcium gluconate over carbonate to balance impaired calcium hemostasis in mice.Introduction: Gastrectomy and hypochlorhydria due to long-term proton pump inhibitor therapy are associated with increased fracture risk because of intestinal calcium malabsorption. Hence, our objectives were to histologically investigat..
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Awarded by Deutsche Forschungsgemeinschaft
Funding Acknowledgements
We thank Dr. rer. medic. Bjorn Busse and Dr. med. dent. Till Koehne for their contribution to assess mineralization data of gastrectomized patients and controls. This work was supported by grants from the German Research Foundation (AM 103/14-2) and the German Federal Ministry of Education and Research within the framework of the project "Molecular Pathology of Osteoporosis" (BMBF, Osteopath 01EC1006) to MA.