Journal article

GENETIC AND BIOCHEMICAL-CHARACTERIZATION OF ANTIGENS ENCODED BY THE LY-24 (PGP-1) LOCUS

VR SUTTON, GL WIJFFELS, ID WALKER, PM HOGARTH, IFC MCKENZIE

JOURNAL OF IMMUNOGENETICS | BLACKWELL SCIENCE LTD | Published : 1987

Abstract

Three allele-specific monoclonal antibodies to Pgp-1 (Ly-24) were used to biochemically characterize the cell surface structures with which they reacted and to map the gene(s) coding for these antigens. The targets of these three monoclonal antibodies (mAb) were shown to be encoded by a gene situated on chromosome 2 close to beta 2m [gene order (Pgp-1-beta 2m-a)] and no recombination between the loci detected by the three antibodies was revealed by genetic analysis. The genetic mapping of loci and tissue distribution of these antigens suggested that they might all correspond to a particular allelic form of the mouse phagocyte glycoprotein-1 (Pgp-1) antigen. Biochemical and serological analys..

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University of Melbourne Researchers