Journal article

THE DISTRIBUTION OF THE QA-2 ALLOANTIGEN ON FUNCTIONAL LYMPHOCYTES-T

PM HOGARTH, A BASTEN, H PRICHARDBRISCOE, MH HENNING, VR SUTTON, IFC MCKENZIE

JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 1985

Abstract

The expression of Qa-2 on functional lymphocytes was investigated in vitro and in vivo by using a monoclonal anti-Qa-2 antibody. In vitro treatment of T cells with antibody and complement demonstrated that T cells mediating help or delayed-type hypersensitivity for anti-SRBC responses were Qa-2+. In addition, cytotoxic T cells and either their precursors or cells involved in their generation were Qa-2+, as were anti-HGG suppressor T cells. Panning techniques were also used to show that secondary suppressor T cells were Qa-2+ and that there may be heterogeneity in suppressor T cells defined by Qa-2 expression. In vivo treatment of mice with anti-Qa-2 resulted in decrease in immune responsiven..

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University of Melbourne Researchers