Journal article
The mouse Fc receptor for IgG (Ly-17) : molecular cloning and specificity
PM Hogarth, ML Hibbs, L Bonadonna, BM Scott, E Witort, GA Pietersz, IFC McKenzie
Immunogenetics | SPRINGER | Published : 1987
DOI: 10.1007/BF00365906
Abstract
A cDNA clone encoding the mouse Ly-17+ Fc receptor for IgG, isolated from a myelomonocytic cell line, was sequenced and expression of mRNA and the functional FcγR investigated. The receptor is a 301 amino acid transmembrane glycoprotein with two homologous extracellular domains that are also homologous to members of the Ig superfamily. The receptor has four sites of N-linked glycosylation and a long 94 amino acid cytoplasmic tail. Northern analysis, immune complex binding, and serological studies demonstrate that the receptor encoded by the cDNA clone binds mouse IgGγ1/2b and rabbit IgG complexes. © 1987 Springer-Verlag.