Cells mediating graft rejection in the mouse. I. Lyt-1 cells mediate skin graft rejection

Abstract

It is commonly accepted that the in vitro lysis of allogeneic target cells by primed cytotoxic T cells (Tc)1 is an appropriate model for studying graft rejection. For example, Tc can be found in grafts undergoing rejection (1-3), in the spleen and other tissues of primed mice (1,4,5), and in sponge matrix grafts (6,7) In addition, extensive in vitro studies have demonstrated the induction and function of Tc, the requirement of helper T cells (Th) for their induction, and the simultaneous induction of suppressor T cells (5, 8-14). In these studies, it has become abundantly clear that the Lyt-123/23-Tc2 is different from Th cells (which are Lyt-1), suppressor T cells, and other T cells. In spi..