Journal article

Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis

Andrea Cipriani, Xinyu Zhou, Cinzia Del Giovane, Sarah E Hetrick, Bin Qin, Craig Whittington, David Coghill, Yuqing Zhang, Philip Hazell, Stefan Leucht, Pim Cuijpers, Juncai Pu, David Cohen, Arun V Ravindran, Yiyun Liu, Kurt D Michael, Lining Yang, Lanxiang Liu, Peng Xie

The Lancet | ELSEVIER SCIENCE INC | Published : 2016


BACKGROUND: Major depressive disorder is one of the most common mental disorders in children and adolescents. However, whether to use pharmacological interventions in this population and which drug should be preferred are still matters of controversy. Consequently, we aimed to compare and rank antidepressants and placebo for major depressive disorder in young people. METHODS: We did a network meta-analysis to identify both direct and indirect evidence from relevant trials. We searched PubMed, the Cochrane Library, Web of Science, Embase, CINAHL, PsycINFO, LiLACS, regulatory agencies' websites, and international registers for published and unpublished, double-blind randomised controlled trial..

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Awarded by National Basic Research Program of China (973 Program)

Funding Acknowledgements

We thank Graham J Emslie and Taryn Mayes from the University of Texas Southwestern Medical Center in Dallas for providing unpublished data in this review, and Salvatore Gentile from the Department of Mental Health, ASL Salerno Mental Health Center, Italy, for his valuable advice. AC is supported by the National Institute for Health Research Oxford Cognitive Health Clinical Research Facility. National Basic Research Program of China (973 Program) (grant number 2009CB918300).