Journal article
A randomized, double-blind, crossover trial comparing a silicone- versus water-based lubricant for sexual discomfort after breast cancer
M Hickey, JL Marino, S Braat, S Wong
Breast Cancer Research and Treatment | SPRINGER | Published : 2016
Abstract
Discomfort during sexual activity is common after breast cancer. Vaginal estrogens are effective but commonly avoided due to systemic absorption. Despite the large commercial market for vaginal lubricants, no randomized studies have compared products. We aimed to compare efficacy and acceptability of two major types of lubricant for discomfort during sexual activity in postmenopausal breast cancer patients. In a single-center, randomized, double-blind, AB/BA crossover design, sexually active postmenopausal breast cancer patients used each lubricant for 4 weeks. The primary patient-reported efficacy outcome was total discomfort related to sexual activity (Fallowfield Sexual Activity Questionn..
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Funding Acknowledgements
The study was partially supported by an educational grant from pjur, Luxembourg, which included supply of both water-and silicone-based lubricants but not packaging for double blinding. The company had no input into the study design, data collection, analysis of findings, interpretation of results, or writing of this manuscript. The pjur group approved the submitted version of this manuscript.