Journal article

Changes in the sympathetic innervation of the gut in rotenone treated mice as possible early biomarker for Parkinson's disease

Mike Arnhold, Yanina Dening, Michael Chopin, Esteban Arevalo, Mathias Schwarz, Heinz Reichmann, Gabriele Gille, Richard HW Funk, Francisco Pan-Montojo

Clinical Autonomic Research | SPRINGER HEIDELBERG | Published : 2016

Abstract

INTRODUCTION: Involvement of the peripheral nervous system (PNS) is relatively common in Parkinson's disease (PD) patients. PNS alterations appear early in the course of the disease and are responsible for some of the non-motor symptoms observed in PD patients. In previous studies, we have shown that environmental toxins can trigger the disease by acting on the enteric nervous system. MATERIAL AND METHODS: Here, we analyzed the effect of mitochondrial Complex I inhibition on sympathetic neuritis in vivo and sympathetic neurons in vitro. Combining in vivo imaging and protein expression profiling. RESULTS: we found that rotenone, a widely used mitochondrial Complex I inhibitor decreases the de..

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University of Melbourne Researchers