Journal article

K/BxN Serum-Transfer Arthritis as a Model for Human inflammatory Arthritis

Anne D Christensen, Claus Haase, Andrew D Cook, John A Hamilton

FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2016

Abstract

The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can be studied. To induce K/BxN STA, serum from arthritic transgenic K/BxN mice is transferred to naive mice and manifestations of arthritis occur a few days later. The inflammatory response in the model is driven by autoantibodies against the ubiquitously expressed self-antigen, glucose-6-phosphate isomerase (G6PI), leading to the formation of immune complexes that drive the activation of different innate immune cells such as neutrophils, macrophages, and possibly mast cells. The pathogenesis further involves a range of immune me..

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Grants

Funding Acknowledgements

This work is the result of a PhD project funded by the Novo Nordisk & Life In Vivo Pharmacology Centre (LIFEPHARM), Denmark (to A.D.Christensen). CH is employed by Novo Nordisk A/S. This work was also supported by a Senior Principal Research Fellowship (to JH) and a Project Grant (to A.D.Cook) from the National Health and Medical Research Council of Australia.