Journal article
K/BxN serum-transfer arthritis as a model for human inflammatory arthritis
AD Christensen, C Haase, AD Cook, JA Hamilton
Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2016
Open access
Abstract
The K/BxN serum-transfer arthritis (STA) model is a murine model in which the immunological mechanisms occurring in rheumatoid arthritis (RA) and other arthritides can be studied. To induce K/BxN STA, serum from arthritic transgenic K/BxN mice is transferred to naive mice and manifestations of arthritis occur a few days later. The inflammatory response in the model is driven by autoantibodies against the ubiquitously expressed self-antigen, glucose-6-phosphate isomerase (G6PI), leading to theformation of immune complexes that drive the activation of different innate immune cells such as neutrophils, macrophages, and possibly mast cells. The pathogenesis further involves a range of immune med..
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Funding Acknowledgements
This work is the result of a PhD project funded by the Novo Nordisk & Life In Vivo Pharmacology Centre (LIFEPHARM), Denmark (to A.D.Christensen). CH is employed by Novo Nordisk A/S. This work was also supported by a Senior Principal Research Fellowship (to JH) and a Project Grant (to A.D.Cook) from the National Health and Medical Research Council of Australia.