Conference Proceedings
Mean absorbed dose to mouse in micro-CT imaging with an ultrafast laser-based x-ray source
A Krol, Y Hongwei, R Kincaid, J Boone, M Servol, JC Kieffer, Y Nesterets, T Gureyev, A Stevenson, S Wilkins, E Lipson, R Toth, A Pogany, I Coman
Progress in Biomedical Optics and Imaging Proceedings of SPIE | SPIE-INT SOC OPTICAL ENGINEERING | Published : 2007
DOI: 10.1117/12.713827
Abstract
We have investigated theoretically the mean absorbed dose to the mouse in our newly constructed, in-line holography, x-ray phase-contrast, in-vivo, micro-CT system with an ultrafast laser-based x-ray (ULX) source. We assumed that the effective mouse diameter was 30 mm and the x-ray detector required minimum 30 μGy per frame to produce high quality images. The following laser target-filter combinations were considered: Ag-Ag, Mo-Mo, Sn-Sn. In addition, we considered narrow-pass multilayer x-ray mirrors. The corresponding ULX spectra were obtained using a CZT solid-state spectrometer. The approach used for dose computation was similar to human dose estimation. The mouse was modeled as a tissue..
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Awarded by NIH NIBIB
Funding Acknowledgements
This research has been supported in part by grant R21 EB005055-02 from NIH NIBIB.