Journal article

Hemodynamic Effects of the Non-Peptidic Angiotensin-(1-7) Agonist AVE0991 in Liver Cirrhosis

Sabine Klein, Chandana B Herath, Robert Schierwagen, Josephine Grace, Tom Haltenhof, Frank E Uschner, Christian P Strassburg, Tilman Sauerbruch, Thomas Walther, Peter W Angus, Jonel Trebicka

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

BACKGROUND & AIMS: Although in cirrhosis with portal hypertension levels of the vasoconstrictor angiotensin II are increased, this is accompanied by increased production of angiotensin (Ang)-(1-7), the endogenous ligand of the Mas receptor (MasR), which blunts hepatic fibrosis and decreases hepatic vascular resistance. Therefore, we investigated the effects of the non-peptidic Ang-(1-7) agonist, AVE0991, in experimental cirrhosis. METHODS: Cirrhosis was induced by bile duct ligation (BDL) or carbon tetrachloride (CCl4) intoxication. The coloured microsphere technique assessed portal and systemic hemodynamic effects of AVE0991 in vivo. Hepatic expression of eNOS, p-eNOS, iNOS, JAK2, ROCK and ..

View full abstract

Grants

Awarded by Deutsche Forschungsgemeinschaft


Awarded by J. & W. Hector- Foundation


Awarded by National Health and Medical Research Council (NHMRC) of Australia


Funding Acknowledgements

The study was supported by grants from the Deutsche Forschungsgemeinschaft (SFB TRR57 P18; WA1441/22-2), J. & W. Hector- Foundation (M60.2) and National Health and Medical Research Council (NHMRC) of Australia (APP1008252).