Journal article

A randomized controlled study of trimethoprim-sulfamethoxazole versus norfloxacin for the prevention of infection in cirrhotic patients

Steve Lontos, Edward Shelton, Peter W Angus, Rhys Vaughan, Stuart K Roberts, Adam Gordon, Paul J Gow

JOURNAL OF DIGESTIVE DISEASES | WILEY-BLACKWELL | Published : 2014

Abstract

OBJECTIVE: To prospectively compare norfloxacin (N) with trimethoprim-sulfamethoxazole (T-S) in preventing infection in cirrhotic patients. METHODS: Cirrhotic patients at high risk of spontaneous bacterial peritonitis (SBP) were recruited and assigned N (400 mg daily) or T-S (160/800 mg daily). Patients were followed up for 12 months. The primary end-point was the incidence of infection. Secondary end-points included the incidence of SBP, bacteremia, extraperitoneal infection requiring antibiotic treatment, liver transplantation, death, side effects and rate of resistance to N or T-S. RESULTS: A total of 80 patients with a mean age of 53.0 ± 9.3 years were prescribed N (n = 40) or T-S (n = 4..

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University of Melbourne Researchers