The Interactions of CPP-ACP with Saliva
Noorjahan Laila Huq, Helen Myroforidis, Keith J Cross, David P Stanton, Paul D Veith, Brent R Ward, Eric C Reynolds
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | MDPI | Published : 2016
The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP-ACP). These complexes consist of an amorphous calcium phosphate mineral phase stabilised and encapsulated by the self-assembly of milk-derived phosphopeptides. During topical application of CPP-ACP complexes in the oral cavity, the CPP encounters the enamel pellicle consisting of salivary proteins and peptides. However the interactions of the CPP with the enamel salivary pellicle are not known. The studies presented here reveal that the predominant peptides of CPP-ACP complexes do interact wi..View full abstract
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This study was supported by the Australian Government, Department of Industry, Innovation and Science.