Journal article
Mould-sensitized adults have lower Th2 cytokines and a higher prevalence of asthma than those sensitized to other aeroallergens
MC Matheson, JC Reece, RK Kandane-Rathnayake, MLK Tang, JA Simpson, IH Feather, MC Southey, H Tsimiklis, JL Hopper, SC Morrison, GG Giles, EH Walters, SC Dharmage
Allergy European Journal of Allergy and Clinical Immunology | WILEY | Published : 2016
DOI: 10.1111/all.12964
Abstract
Background: Evidence suggests that specific allergen sensitizations are associated with different allergic diseases which may reflect different underlying immune profiles. We aimed to examine the cytokine profiles of individuals sensitized to eight common aeroallergens. Methods: We used data from the Tasmanian Longitudinal Health Study a population-based cohort study of 45-year-olds. Serum cytokines (IL-4, IL-5, IL-6, IL-8, IL-10, TNF-α) were measured in 1157 subjects using the LINCOplex assays. Participants underwent skin prick testing for house dust mite, cat, grasses and moulds. Multivariable linear regression was used to compare serum cytokine levels between sensitized and nonatopic subj..
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