Journal article

Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas

Andrew Neal, Tanya Yuen, Andrew R Bjorksten, Patrick Kwan, Terence J O'Brien, Andrew Morokoff

JOURNAL OF NEURO-ONCOLOGY | SPRINGER | Published : 2016

Abstract

To examine the impact of glutamate on post-operative seizures and survival in a cohort of patients with grade II to IV supratentorial glioma. A retrospective analysis was performed on 216 patients who underwent surgery for supratentorial gliomas. Primary explanatory variables were peritumoural and/or tumoural glutamate concentrations, glutamate transporter expression (EAAT2 and SXC). Univariate and multivariate survival analysis was performed with primary outcomes of time to first post-operative seizure and overall survival. Subgroup analysis was performed in patients with de novo glioblastomas who received adjuvant chemoradiotherapy. 47 (21.8 %), 34 (15.8 %) and 135 (62.5 %) WHO grade II, I..

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