Peritumoural glutamate correlates with post-operative seizures in supratentorial gliomas
Andrew Neal, Tanya Yuen, Andrew R Bjorksten, Patrick Kwan, Terence J O'Brien, Andrew Morokoff
JOURNAL OF NEURO-ONCOLOGY | SPRINGER | Published : 2016
To examine the impact of glutamate on post-operative seizures and survival in a cohort of patients with grade II to IV supratentorial glioma. A retrospective analysis was performed on 216 patients who underwent surgery for supratentorial gliomas. Primary explanatory variables were peritumoural and/or tumoural glutamate concentrations, glutamate transporter expression (EAAT2 and SXC). Univariate and multivariate survival analysis was performed with primary outcomes of time to first post-operative seizure and overall survival. Subgroup analysis was performed in patients with de novo glioblastomas who received adjuvant chemoradiotherapy. 47 (21.8 %), 34 (15.8 %) and 135 (62.5 %) WHO grade II, I..View full abstract
Dr. Andrew Neal was supported by an Australian Postgraduate Award Scholarship (University of Melbourne), The UCB Pharma Clinical Scholarship and by the Royal Melbourne Hospital Neuroscience Foundation.