Adrenal, metabolic and cardio-renal dysfunction develops after pregnancy in rats born small or stressed by physiological measurements during pregnancy
Jean N Cheong, James SM Cuffe, Andrew J Jefferies, Karen M Moritz, Mary E Wlodek
JOURNAL OF PHYSIOLOGY-LONDON | WILEY | Published : 2016
KEY POINTS: Women born small are at an increased risk of developing pregnancy complications. Stress may further increase a woman's likelihood for an adverse pregnancy. Adverse pregnancy adaptations can lead to long-term diseases even after her pregnancy. The current study investigated the effects of stress during pregnancy on the long-term adrenal, metabolic and cardio-renal health of female rats that were born small. Stress programmed increased adrenal Mc2r gene expression, a higher insulin secretory response to glucose during intraperitoneal glucose tolerance test (+36%) and elevated renal creatinine clearance after pregnancy. Females that were born small had increased homeostatic model as..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was funded by the National Health and Medical Research Council of Australia (Grant no. 1025426) awarded to M.E.W. and K.M.M.