Journal article

Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study

Kavitha Krishnan, Laura Baglietto, Carmel Apicella, Jennifer Stone, Melissa C Southey, Dallas R English, Graham G Giles, John L Hopper



BACKGROUND: Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent risk and risk of masking (risk of the tumor not being detected due to increased dense tissue). Therefore the predictors of whether a breast cancer is interval or screen-detected include those that predict masking. Our aim was to investigate the associations between mammographic measures and (1) inherent risk, and (2) masking. METHODS: We conducted a case-control study nested within the Melbourne collaborative cohort study of 244 screen-detected cases (192 small tumors (<2 cm)) matched to 700 controls and 148 interval cases (76 small tumors) matched to 446 controls...

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

MCCS was funded by VicHealth and the Cancer Council of Victoria. This work was supported by the Victorian Breast Cancer Research Consortium, the National Health and Medical Research Council (251533, 209057, and 504711), and the National Breast Cancer Foundation and was further supported by infrastructure provided by the Cancer Council Victoria and the University of Melbourne. We thank the Victorian Cancer Registry, BreastScreen Victoria, the Australian Mammographic Density Research Facility, and Christopher Evans for reading the MCCS mammograms. KK is supported by the John and Allan Gilmour Research Award and the May Stewart Bursary scholarships. JLH is a Senior Principal Research Fellow of the National Health and Medical Research Council and a Redmond Barry Distinguished Professor of the University of Melbourne. MCS is a Senior Research Fellow of the National Health and Medical Research Council. LB is supported by a Marie Curie International Incoming Fellowship within the 7th European Community Framework Programme.