Journal article

A 2-Substituted 8-Hydroxyquinoline Stimulates Neural Stem Cell Proliferation by Modulating ROS Signalling

Cathryn L Haigh, Carolin Tumpach, Steven J Collins, Simon C Drew

CELL BIOCHEMISTRY AND BIOPHYSICS | HUMANA PRESS INC | Published : 2016

Abstract

Eight-hydroxyquinolines (8HQs) are a class of compounds that have been identified as potential therapeutics for a number of neurodegenerative diseases. Understanding the influence of structural modifications to the 8HQ scaffold on cellular behaviour will aid the identification of compounds that might be effective in treating dementias. In this study, we describe the action of 2-[(dimethylamino)methyl]-8-hydroxyquinoline (DMAMQ) on adult murine neural stem cells (NSCs) cultured in vitro. Treatment of NSCs with DMAMQ resulted in enhanced self-renewal and increased neurite outgrowth. Concurrent with the positive growth effects was an increase in intracellular reactive oxygen species, with the g..

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Awarded by Future Fellowship



Funding Acknowledgements

This work was supported by a Future Fellowship (FT110100199) administered by the Australian Research Council (S.C.D.), a Program Grant (#628946; S.J.C.) and Practitioner Fellowship (APP1005816; S.J.C.) administered by the National Health and Medical Research Council of Australia.