More parasiticmyositis cases in humans in Australia, and the definition of genetic markers for the causative agents as a basis for molecular diagnosis
Anson V Koehler, David M Spratt, Robert Norton, Sanchia Warren, Belinda McEwan, Ravindra Urkude, Suresh Murthy, Thomas Robertson, Naomi McCallum, Fiona Parsonson, Richard S Bradbury, Robin B Gasser
INFECTION GENETICS AND EVOLUTION | ELSEVIER SCIENCE BV | Published : 2016
Since 1998, there have been six reported human cases of myositis in Australia, attributable to infection with the nematode Haycocknema perplexum. However, an unequivocal diagnosis of H. perplexum infection and associated disease has been seriously compromised by a lack of molecular markers for this nematode. Here, we report new cases of disseminated myositis in two male patients from the states of Queensland and Tasmania in Australia, respectively; genetically characterize the causative agent from each case; and, also establish a PCR-based sequencing approach as a tool to support the diagnosis of future cases and to underpin epidemiological studies.
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We thank Drs Alison Ratcliffe, Tara Anderson and Peter Jessup for patient care or histopathological examination. RBG's research is supported by grants from the National Health and Medical Research Council (NHMRC) and Australian Research Council (ARC), Melbourne Water Corporation and Yourgene Biosciences (Dr Bill Chang). Neil Young assisted with RAxML, and Ross Hall with phylogenetic analysis.