Journal article
Toll-like receptor expression and signaling in peripheral blood mononuclear cells correlate with clinical outcomes in acute hepatitis c virus infection
SLG Chen Yi Mei, J Burchell, N Skinner, R Millen, G Matthews, M Hellard, GJ Dore, PV Desmond, V Sundararajan, AJ Thompson, K Visvanathan, J Sasadeusz
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2016
Abstract
Background. Mechanisms by which spontaneous clearance of acute hepatitis C occurs are unclear. A critical role for the innate immune system and IFNL4 polymorphisms has been proposed. This study investigates whether Toll-like receptor (TLR) expression and signaling during acute hepatitis C correlates with clinical outcomes. Methods. Participants identified fromthe Australian Trial in Acute Hepatitis C and the Networks study were followed longitudinally from the time of diagnosis of acute hepatitis C. Peripheral blood mononuclear cells (PBMCs) and plasma were collected at and 2 time points after diagnosis. At each time point, TLR2, TLR4, and CD86 expression on peripheral blood monocytes, natur..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Gastroenterological Society of Australia (postgraduate clinical research scholarship); the National Institute on Drug Abuse, NIH (award R01DA015999 to the ATAHC); the Australian Department of Health and Ageing (funding to the Kirby Institute); the National Health and Medical Research Council (project grant 331212 to the Networks study); and the Victorian government (operational infrastructure support to the Burnet Institute).