Toll-like Receptor Expression and Signaling in Peripheral Blood Mononuclear Cells Correlate With Clinical Outcomes in Acute Hepatitis C Virus Infection
Swee Lin G Chen Yi Mei, Jodie Burchell, Narelle Skinner, Rosie Millen, Gail Matthews, Margaret Hellard, Gregory J Dore, Paul V Desmond, Vijaya Sundararajan, Alexander J Thompson, Kumar Visvanathan, Joe Sasadeusz
The Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2016
BACKGROUND: Mechanisms by which spontaneous clearance of acute hepatitis C occurs are unclear. A critical role for the innate immune system and IFNL4 polymorphisms has been proposed. This study investigates whether Toll-like receptor (TLR) expression and signaling during acute hepatitis C correlates with clinical outcomes. METHODS: Participants identified from the Australian Trial in Acute Hepatitis C and the Networks study were followed longitudinally from the time of diagnosis of acute hepatitis C. Peripheral blood mononuclear cells (PBMCs) and plasma were collected at and 2 time points after diagnosis. At each time point, TLR2, TLR4, and CD86 expression on peripheral blood monocytes, natu..View full abstract
Awarded by National Institute on Drug Abuse, NIH
Awarded by National Health and Medical Research Council
Awarded by NATIONAL INSTITUTE ON DRUG ABUSE
This work was supported by the Gastroenterological Society of Australia (postgraduate clinical research scholarship); the National Institute on Drug Abuse, NIH (award R01DA015999 to the ATAHC); the Australian Department of Health and Ageing (funding to the Kirby Institute); the National Health and Medical Research Council (project grant 331212 to the Networks study); and the Victorian government (operational infrastructure support to the Burnet Institute).