Journal article

The Association of Type 2 Diabetes Mellitus with Cerebral Gray Matter Volume Is Independent of Retinal Vascular Architecture and Retinopathy

C Moran, RJ Tapp, AD Hughes, CG Magnussen, L Blizzard, TG Phan, R Beare, N Witt, A Venn, G Munch, BC Amaratunge, V Srikanth



It is uncertain whether small vessel disease underlies the relationship between Type 2 Diabetes Mellitus (T2DM) and brain atrophy. We aimed to study whether retinal vascular architecture, as a proxy for cerebral small vessel disease, may modify or mediate the associations of T2DM with brain volumes. In this cross-sectional study using Magnetic Resonance Imaging (MRI) scans and retinal photographs in 451 people with and without T2DM, we measured brain volumes, geometric measures of retinal vascular architecture, clinical retinopathy, and MRI cerebrovascular lesions. There were 270 people with (mean age 67.3 years) and 181 without T2DM (mean age 72.9 years). T2DM was associated with lower gray..

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Awarded by National Health and Medical Research Council (NHMRC), Australia

Awarded by National Heart Foundation/NHMRC

Awarded by NHMRC

Awarded by British Heart Foundation

Funding Acknowledgements

This study was funded by the National Health and Medical Research Council (NHMRC) (Project Grants 403000 and 436797), Australia. C. Moran is a recipient of a Monash School of Clinical Sciences Early Career Practitioner Fellowship. V. Srikanth is a recipient of a National Heart Foundation/NHMRC Career Development Fellowship (606544) and NHMRC Project Grants (403000 and 436797).