Journal article
Firing frequency and entrainment maintained in primary auditory neurons in the presence of combined BDNF and NT3
T Wright, LN Gillespie, SJ O'Leary, K Needham
Scientific Reports | NATURE PORTFOLIO | Published : 2016
DOI: 10.1038/srep28584
Abstract
Primary auditory neurons rely on neurotrophic factors for development and survival. We previously determined that exposure to brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3) alters the activity of hyperpolarization-activated currents (Ih) in this neuronal population. Since potassium channels are sensitive to neurotrophins, and changes in Ih are often accompanied by a shift in voltage-gated potassium currents (IK), this study examined IK with exposure to both BDNF and NT3 and the impact on firing entrainment during high frequency pulse trains. Whole-cell patch-clamp recordings revealed significant changes in action potential latency and duration, but no change in firing adap..
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Funding Acknowledgements
KN is supported by a Senior Wagstaff Fellowship in Otolaryngology (Royal Victorian Eye and Ear Hospital). This work has been supported by The University of Melbourne, and The Royal Victorian Eye and Ear Hospital. The funding bodies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.