Journal article
Early life events predict adult testicular function; Data derived from the Western Australian (Raine) birth cohort
RJ Hart, DA Doherty, JA Keelan, R McLachlan, NE Skakkebaek, RJ Norman, JE Dickinson, CE Pennell, JP Newnham, M Hickey, DJ Handelsman
Journal of Clinical Endocrinology and Metabolism | ENDOCRINE SOC | Published : 2016
DOI: 10.1210/jc.2016-1646
Abstract
Context: The impact of early life events on testicular function in adulthood is not well understood. Objective: To study the early influences of fetal growth, exposures to cigarette smoke in utero and cord blood estrogens, and the influences of growth and adiposity in childhood through adolescence; on testicular function in adulthood. Design: Male members of the Western Australian Pregnancy Cohort (Raine) were contacted at 20-22 years of age. Of 913 contacted, 423 (56%) agreed to participate; 404 underwent a testicular ultrasound, 365 provided a semen sample, and reproductive hormones were measured (384). Fetal growth measurements (n = 137), umbilical cord estrogen concentrations (n = 128), ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We thank The Raine Study participants who took part in this study and The Raine Study Team for cohort coordination and data collection. We also thank The Raine Medical Research Foundation, The Telethon Kids Institute, The University of Western Australia, The University of Western Australia Faculty of Medicine, Dentistry and Health Sciences, Women's and Infant's Research Foundation, Curtin University, and Edith Cowan University for providing core management funding. We particularly thank Alex Baptista and Jenny Mountain of The Raine Study Team, Michele Pedretti for performing the ultrasound examinations, and the staff of FSWA for facilitating the semen assessments.This work was supported by the National Health and Medical Research Council Project Grant 634557. This work was also supported by The Raine Medical Research Foundation, The Telethon Kids Institute, The University of Western Australia, Women and Infant Research Foundation, Curtin University, and Edith Cowan University.