Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: Epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-study

P Rzehak; R Saffery; E Reischl; M Covic; S Wahl; V Grote; A Xhonneux; JP Langhendries; N Ferre; R Closa-Monasterolo; E Riva; P Socha; D Gruszfeld; B Koletzko; P Goyens; C Carlier; J Hoyos; P Poncelet; E Dain; JN Van Hees; F Martin; J Escribano; V Luque; G Mendez; M Zaragoza-Jordana; M Giovannini; C Agostoni; S Scaglioni; E Verduci; F Vecchi; A Re Dionigi; J Socha; A Stolarczyk; A Dobrzanska; R Janas; E Perrin; R Von Kries; H Groebe; A Reith; R Hofmann; M Weber; S Schiess; J Beyer; M Fritsch; U Handel; I Pawellek; S Verwied-Jorky; I Hannibal; H Demmelmair; G Haile; M Theurich

Journal article

Maternal smoking during pregnancy and DNA-methylation in children at age 5.5 years: Epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-study

P Rzehak, R Saffery, E Reischl, M Covic, S Wahl, V Grote, A Xhonneux, JP Langhendries, N Ferre, R Closa-Monasterolo, E Riva, P Socha, D Gruszfeld, B Koletzko, P Goyens, C Carlier, J Hoyos, P Poncelet, E Dain, JN Van Hees Show all

Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016

DOI: 10.1371/journal.pone.0155554

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Abstract

Mounting evidence links prenatal exposure to maternal tobacco smoking with disruption of DNA methylation (DNAm) profile in the blood of infants. However, data on the postnatal stability of such DNAm signatures in childhood, as assessed by Epigenome Wide Association Studies (EWAS), are scarce. Objectives of this study were to investigate DNAm signatures associated with in utero tobacco smoke exposure beyond the 12th week of gestation in whole blood of children at age 5.5 years, to replicate previous findings in young European and American children and to assess their biological role by exploring databases and enrichment analysis. DNA methylation was measured in blood of 366 children of the mu..

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University of Melbourne Researchers

Richard Saffery Author

Grants

Awarded by European Commission

Funding Acknowledgements

The studies and research reported herein were partially supported by the Commission of the European Community, specific RTD Programme "Quality of Life and Management of Living Resources," within the 5th Framework Programme (research grant nos. QLRT-2001-00389 and QLK1-CT-2002-30582); the 6th Framework Programme contract no. 007036); the European Union's Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition under grant agreement no. 289346 and the European Research Council Advanced Grant ERC-2012-AdG - no. 322605 META-GROWTH. This manuscript does not necessarily reflect the views of the Commission and in no way anticipates the future policy in this area. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.