Taking out the JNK: A window of opportunity to improve cancer therapy
Petranel T Ferrao
MOLECULAR & CELLULAR ONCOLOGY | TAYLOR & FRANCIS INC | Published : 2016
c-JUN-N-terminal kinase (JNK) signaling is a stress-induced response that enables survival of normal cells and is also utilized by cancer cells to evade therapy. Combining JNK inhibitors with standard therapies provides a potential strategy for overcoming drug resistance. Use of the optimal combination dosing and scheduling may substantially improve outcomes for cancer patients.