Journal article

The effect of pulmonary function testing on bleomycin dosing in germ cell tumours

FT Roncolato, M Chatfield, B Houghton, G Toner, M Stockler, D Thomson, M Friedlander, H Gurney, M Rosenthal, P Grimison

INTERNAL MEDICINE JOURNAL | WILEY-BLACKWELL | Published : 2016

Abstract

BACKGROUND/AIM: The utility of pulmonary function testing (PFT) to detect bleomycin-induced pneumonitis is controversial. We describe its impact on bleomycin dosing in a phase 2 trial of accelerated BEP (bleomycin, etoposide, cisplatin) for advanced germ cell tumours. METHODS: There were 12 planned weekly bleomycin doses for intermediate-risk and poor-risk disease and nine for good-risk disease. Clinical assessments, chest X-ray, diffusing capacity of lung for carbon monoxide (DLCO) and forced vital capacity (FVC) were performed bi-weekly. Bleomycin was ceased for predefined clinical/radiological evidence of pulmonary toxicity and a >25% reduction in DLCO or FVC. We determined doses planned,..

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