Journal article
Heterologous vaccine effects
M Saadatian-Elahi, P Aaby, F Shann, MG Netea, O Levy, J Louis, V Picot, M Greenberg, W Warren
Vaccine | ELSEVIER SCI LTD | Published : 2016
Abstract
The heterologous or non-specific effects (NSEs) of vaccines, at times defined as “off-target effects” suggest that they can affect the immune response to organisms other than their pathogen-specific intended purpose. These NSEs have been the subject of clinical, immunological and epidemiological studies and are increasingly recognized as an important biological process by a growing group of immunologists and epidemiologists. Much remain to be learned about the extent and underlying mechanisms for these effects. The conference “Off-target effects of vaccination” held in Annecy-France (June 8–10 2015) intended to take a holistic approach drawing from the fields of immunology, systems biology, ..
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Awarded by Sanofi Pasteur
Funding Acknowledgements
MGN was supported by an ERC Consolidator Grant (#310372).OL's laboratory is supported by Global Health (OPPGH5284) and Grand Challenges Explorations (OPP1035192) awards from the Bill & Melinda Gates Foundation, by NIH grants 1R01AI100135-01 and 3R01AI067353-05S1 as well as National Institute of Allergy & Infectious Diseases Adjuvant Discovery Program Contract No. HHSN272201400052C and by a philanthropic gift from Henry and Carol Goldberg to the Precision Vaccines Program.PA's work on non-specific effects of vaccines has been supported by the Danish Council for Development Research, Ministry of Foreign Affairs, Denmark [grant number 104.Dan.8.f.], Novo Nordisk Foundation, European Union FP7 support for OPTIMUNISE (grant: Health-F3-2011-261375) and by a grant from the Danish National Research Foundation (DNRF108).