Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions
Peter Jonsson, Jennifer H Southcombe, Ana Mafalda Santos, Jiandong Huo, Ricardo A Fernandes, James McColl, Melissa Lever, Edward J Evans, Alexander Hudson, Veronica T Chang, Tomas Hanke, Andrew Godkin, Paul D Dunne, Mathew H Horrocks, Matthieu Palayret, Gavin R Screaton, Jan Petersen, Jamie Rossjohn, Lars Fugger, Omer Dushek Show all
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2016
Awarded by Swedish Research Council
Awarded by Sir Henry Dale Fellowship - Wellcome Trust
Awarded by Sir Henry Dale Fellowship - Royal Society
Awarded by Medical Research Council
We thank Professor P. A. van der Merwe and Dr. Marco Fritzsche for helpful comments on the manuscript and Dr. Hugh Reid for technical advice on pMHC II expression. This work was supported by the Wellcome Trust, the UK Medical Research Council, and the Swedish Research Council Grants 623-2014-6387 and 621-2014-3907 (to P.J.). O.D. is supported by the Sir Henry Dale Fellowship Grant 098363 jointly funded by the Wellcome Trust and the Royal Society.