Journal article
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
David K Cole, Anna M Bulek, Garry Dolton, Andrea J Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J Miles, Mark Peakman, Linda Wooldridge, Pierre J Rizkallah, Andrew K Sewell
Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2016
DOI: 10.1172/JCI85679
Grants
Awarded by UK Biotechnology and Biological Sciences Research Council
Awarded by US NIH
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Awarded by Biotechnology and Biological Sciences Research Council
Awarded by Wellcome Trust
Funding Acknowledgements
Primary support for this work was provided by the UK Biotechnology and Biological Sciences Research Council (grant BB/H001085/1). A.K. Sewell is a Wellcome Trust Investigator. D.K. Cole is a Wellcome Trust Research Career Development Fellow (WT095767). P.J. Rizkallah was supported by a RCUK Fellowship. Support for 2D affinity studies was provided by US NIH (grant R01AI124680-01 and R01GM096187 to C. Zhu). We thank the MX staff on beamlines IO2, IO3, IO4-1, and I24, as well as CD staff on beamline B23 at DLS for providing facilities and support.