Journal article

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity

David K Cole, Anna M Bulek, Garry Dolton, Andrea J Schauenberg, Barbara Szomolay, William Rittase, Andrew Trimby, Prithiviraj Jothikumar, Anna Fuller, Ania Skowera, Jamie Rossjohn, Cheng Zhu, John J Miles, Mark Peakman, Linda Wooldridge, Pierre J Rizkallah, Andrew K Sewell

Journal of Clinical Investigation | AMER SOC CLINICAL INVESTIGATION INC | Published : 2016

University of Melbourne Researchers

Grants

Awarded by UK Biotechnology and Biological Sciences Research Council


Awarded by US NIH


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Awarded by Biotechnology and Biological Sciences Research Council


Awarded by Wellcome Trust


Funding Acknowledgements

Primary support for this work was provided by the UK Biotechnology and Biological Sciences Research Council (grant BB/H001085/1). A.K. Sewell is a Wellcome Trust Investigator. D.K. Cole is a Wellcome Trust Research Career Development Fellow (WT095767). P.J. Rizkallah was supported by a RCUK Fellowship. Support for 2D affinity studies was provided by US NIH (grant R01AI124680-01 and R01GM096187 to C. Zhu). We thank the MX staff on beamlines IO2, IO3, IO4-1, and I24, as well as CD staff on beamline B23 at DLS for providing facilities and support.