Journal article

Mouse Models of Tumor Immunotherapy

Shin Foong Ngiow, Sherene Loi, David Thomas, Mark J Smyth, RD Schreiber (ed.)

TUMOR IMMUNOLOGY | ELSEVIER ACADEMIC PRESS INC | Published : 2016

Abstract

Immunotherapy is now evolving into a major therapeutic option for cancer patients. Such clinical advances also promote massive interest in the search for novel immunotherapy targets, and to understand the mechanism of action of current drugs. It is projected that a series of novel immunotherapy agents will be developed and assessed for their therapeutic activity. In light of this, in vivo experimental mouse models that recapitulate human malignancies serve as valuable tools to validate the efficacy and safety profile of immunotherapy agents, before their transition into clinical trials. In this review, we will discuss the major classes of experimental mouse models of cancer commonly used for..

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