Oncogene addiction and immunity: clinical implications of tumour infiltrating lymphocytes in breast cancers overexpressing the HER2/neu oncogene
Peter Savas, Franco Caramia, Zhi Ling Teo, Sherene Loi
CURRENT OPINION IN ONCOLOGY | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
PURPOSE OF REVIEW: To review the evidence that correlates tumour infiltrating lymphocytes, a surrogate biomarker of pre-existing host antitumour immunity, and survival in HER2-overexpressing breast cancers. This is of particular relevance to developing immune biomarkers and harnessing new immunotherapeutics in this breast cancer subtype. RECENT FINDINGS: Oncogene addiction, in which cancer cells become reliant on a single oncogenic pathway for tumour growth and progression, has traditionally been thought of as a cell intrinsic characteristic. However, increasing evidence from multiple studies exploring the relationship between markers of an antitumour immune response and clinical outcome in ..View full abstract
Sherene Loi and her laboratory are supported by Cancer Council Victoria, Australia and the National Health and Medical Research Council Australia (NHMRC).