Journal article

GSTM1 null polymorphism and susceptibility to endometriosis and ovarian cancer

SW Baxter, EJ Thomas, IG Campbell

CARCINOGENESIS | OXFORD UNIV PRESS | Published : 2001

Abstract

It is likely that heritable genetic factors contribute to the development of endometriosis, which is a putative precursor of the endometrioid and clear cell histological subtypes of ovarian cancer. The phase II glutathione S-transferases (GSTs) are a family of enzymes responsible for metabolism of a broad range of xenobiotics and carcinogens. Allelic variants of GSTs that have impaired detoxification function may increase the rate of genetic damage and thereby increase the susceptibility to cancer. The null genetic polymorphism in the gene encoding the GST class mu (GSTM1) enzyme has been reported to be significantly elevated in endometriosis patients and may represent an endometriosis susce..

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University of Melbourne Researchers