Journal article

NESIDIOBLASTOSIS AND MULTIFOCAL PANCREATIC-ISLET CELL HYPERPLASIA IN AN ADULT - CLINICOPATHOLOGIC FEATURES AND INVITRO PANCREATIC STUDIES

IL CAMPBELL, LC HARRISON, CJ LEY, PG COLMAN, DW ELLIS

American Journal of Clinical Pathology | LIPPINCOTT-RAVEN PUBL | Published : 1985

Abstract

The clinicopathologic features of an adult with insulinoma and pancreatic islet cell hyperplasia, who presented with hyperinsulinemic hypoglycemia are reported, together with in vitro studies on the patient's pancreatic islets. Islet cell hyperplasia with ductal proliferation and budding and beta cell degranulation was demonstrated by immunochemical means. The in vitro studies of cultured hyperplastic islet cells support the clinicopathologic features. Thus, in comparison with control islets maintained in culture for up to 14 days, hyperplastic islets could be cultured for up to 60 days, during which time cell overgrowth required subculture on three occasions. Furthermore, in contrast to con..

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