Journal article
A radiobiology-based inverse treatment planning method for optimisation of permanent l-125 prostate implants in focal brachytherapy
A Haworth, C Mears, JM Betts, HM Reynolds, G Tack, K Leo, S Williams, MA Ebert
Physics in Medicine and Biology | IOP PUBLISHING LTD | Published : 2015
Abstract
Treatment plans for ten patients, initially treated with a conventional approach to low dose-rate brachytherapy (LDR, 145 Gy to entire prostate), were compared with plans for the same patients created with an inverse-optimisation planning process utilising a biologically-based objective. The 'biological optimisation' considered a non-uniform distribution of tumour cell density through the prostate based on known and expected locations of the tumour. Using dose planning-objectives derived from our previous biological-model validation study, the volume of the urethra receiving 125% of the conventional prescription (145 Gy) was reduced from a median value of 64% to less than 8% whilst maintaini..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by PdCCRS grant 628592 with funding partners: Prostate Cancer Foundation of Australia, Radiation Oncology Section of the Australian Government Department of Health and Cancer Australia. This work was also sponsored by the Australian Research Council grant DP110102258. Dr Reynolds is funded by a Movember Young Investigator Grant awarded through Prostate Cancer Foundation of Australia's Research Program. NICTA is funded by the Australian Government through the Department of Broadband, Communications and the Digital Economy and the Australian Research Council through the ICT Centre of Excellence program.