An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates
Martin Carolan, Brad Oborn, Kerwyn Foo, Annette Haworth, Sarah Gulliford, Martin Ebert
Journal of Physics Conference Series | IOP PUBLISHING LTD | Published : 2014
The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. © Published under licence by IOP Publishing Ltd.
Awarded by NHMRC
This work is supported by NHMRC Project Grant 1006447. We thank Dr Anthony Carolan for useful discussions on parametric and non parametric bootstrapping.