Journal article

An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

Martin Carolan, Brad Oborn, Kerwyn Foo, Annette Haworth, Sarah Gulliford, Martin Ebert

Journal of Physics Conference Series | IOP PUBLISHING LTD | Published : 2014


The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program. © Published under licence by IOP Publishing Ltd.

University of Melbourne Researchers


Awarded by NHMRC

Funding Acknowledgements

This work is supported by NHMRC Project Grant 1006447. We thank Dr Anthony Carolan for useful discussions on parametric and non parametric bootstrapping.