Journal article

Integrated genomic analyses of ovarian carcinoma

D Bell, A Berchuck, M Birrer, J Chien, DW Cramer, F Dao, R Dhir, P DiSaia, H Gabra, P Glenn, AK Godwin, J Gross, L Hartmann, M Huang, DG Huntsman, M Iacocca, M Imielinski, S Kalloger, BY Karlan, DA Levine Show all

Nature | NATURE PUBLISHING GROUP | Published : 2011

Abstract

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients' lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; ..

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Grants

Awarded by USA National Institutes of Health


Awarded by NATIONAL CANCER INSTITUTE


Awarded by NATIONAL HUMAN GENOME RESEARCH INSTITUTE


Awarded by NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH


Funding Acknowledgements

We thank J. Palchik, A. Mirick and Julia Zhang for administrative coordination of TCGA activities. This work was supported by the following grants from the USA National Institutes of Health: U54HG003067, U54HG003079, U54HG003273, U24CA126543, U24CA126544, U24CA126546, U24CA126551, U24CA126554, U24CA126561, U24CA126563, U24CA143840, U24CA143882, U24CA143731, U24CA143835, U24CA143845, U24CA143858, U24CA144025, U24CA143882, U24CA143866, U24CA143867, U24CA143848, U24CA143843 and R21CA135877.