Integrated genomic analyses of ovarian carcinoma

D Bell; A Berchuck; M Birrer; J Chien; DW Cramer; F Dao; R Dhir; P Disaia; H Gabra; P Glenn; AK Godwin; J Gross; L Hartmann; M Huang; DG Huntsman; M Iacocca; M Imielinski; S Kalloger; BY Karlan; DA Levine; GB Mills; C Morrison; D Mutch; N Olvera; S Orsulic; K Park; N Petrelli; B Rabeno; JS Rader; BI Sikic; K Smith-Mccune; AK Sood; D Bowtell; R Penny; JR Testa; K Chang; HH Dinh; JA Drummond; G Fowler; P Gunaratne; AC Hawes; CL Kovar; LR Lewis; MB Morgan; IF Newsham; J Santibanez; JG Reid; LR Trevino; YQ Wu; M Wang; DM Muzny; DA Wheeler; RA Gibbs; G Getz; MS Lawrence; K Cibulskis; AY Sivachenko; C Sougnez; D Voet; J Wilkinson; T Bloom; K Ardlie; T Fennell; J Baldwin; S Gabriel; ES Lander; L Ding; RS Fulton; DC Koboldt; MD McLellan; T Wylie; J Walker; M O'Laughlin; DJ Dooling; L Fulton; R Abbott; ND Dees; Q Zhang; C Kandoth; M Wendl; W Schierding; D Shen; CC Harris; H Schmidt; J Kalicki; KD Delehaunty; CC Fronick; R Demeter; L Cook; JW Wallis; L Lin; VJ Magrini; JS Hodges; JM Eldred; SM Smith; CS Pohl; F Vandin; BJ Raphael; GM Weinstock; ER Mardis

Journal article

Integrated genomic analyses of ovarian carcinoma

D Bell, A Berchuck, M Birrer, J Chien, DW Cramer, F Dao, R Dhir, P Disaia, H Gabra, P Glenn, AK Godwin, J Gross, L Hartmann, M Huang, DG Huntsman, M Iacocca, M Imielinski, S Kalloger, BY Karlan, DA Levine Show all

Nature | Published : 2011

DOI: 10.1038/nature10166

Open access

Abstract

A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients lives. The Cancer Genome Atlas project has analysed messenger RNA expression, microRNA expression, promoter methylation and DNA copy number in 489 high-grade serous ovarian adenocarcinomas and the DNA sequences of exons from coding genes in 316 of these tumours. Here we report that high-grade serous ovarian cancer is characterized by TP53 mutations in almost all tumours (96%); low prevalence but statistically recurrent somatic mutations in nine further genes including NF1, BRCA1, BRCA2, RB1 and CDK12; 113 significant focal DNA copy number aberrations; a..

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University of Melbourne Researchers

David Bowtell Author

Michael Lawrence Author

Terence Speed Author

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

We thank J. Palchik, A. Mirick and Julia Zhang for administrative coordination of TCGA activities. This work was supported by the following grants from the USA National Institutes of Health: U54HG003067, U54HG003079, U54HG003273, U24CA126543, U24CA126544, U24CA126546, U24CA126551, U24CA126554, U24CA126561, U24CA126563, U24CA143840, U24CA143882, U24CA143731, U24CA143835, U24CA143845, U24CA143858, U24CA144025, U24CA143882, U24CA143866, U24CA143867, U24CA143848, U24CA143843 and R21CA135877.