Journal article

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

Iva A Tchasovnikarova, Richard T Timms, Nicholas J Matheson, Kim Wals, Robin Antrobus, Berthold Goettgens, Gordon Dougan, Mark A Dawson, Paul J Lehner

Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2015


Awarded by Wellcome Trust

Awarded by Biotechnology and Biological Sciences Research Council

Awarded by Cancer Research UK

Awarded by Medical Research Council

Funding Acknowledgements

We thank J. Sinclair, L. Dolken, A. Schuldt, N. Wilson, and F. Calero-Nieto for helpful discussion; R. Schulte and his team for FACS; M. Gratian, M. Bowen, and K. Jayawardena (Cambridge Institute for Medical Research); N. Smerdon (Wellcome Trust Sanger Institute); and S. Andrews (Babraham Institute) for SeqMonk customization. Supported by Wellcome Trust Principal Research Fellowship 101835/Z/13/Z (P.J.L.), a Wellcome Trust studentship (I.A.T.), an MRC Centenary Award (R.T.T.), and the Cambridge Biomedical Research Centre. The Cambridge Institute for Medical Research is in receipt of a Wellcome Trust Strategic Award. Raw sequence data are archived at Gene Expression Omnibus (GSE60056 and GSE63116) and Sequence Read Archive (PRJNA257239).