Circulating tumor cells and circulating tumor DNA for precision medicine: dream or reality?
M Ignatiadis, S-J Dawson
ANNALS OF ONCOLOGY | OXFORD UNIV PRESS | Published : 2014
Next-generation sequencing studies have provided further evidence to support the notion that cancer is a disease characterized by Darwinian evolution. Today, we often fail to capture this evolution and treatment decisions, even in the metastatic setting, are often based on analysis of primary tumor diagnosed years ago. Currently, this is considered a major reason for treatment failures in cancer care. Recent technological advances in the detection and characterization of circulating tumor cells and circulating tumor DNA might address this and allow for treatment tailoring based on real-time monitoring of tumor evolution. In this review, we summarize the most important recent findings in the ..View full abstract
Awarded by National Breast Cancer Foundation
MI received funding by Fonds de la recherche scientifique (FNRS), from Breast Cancer Research Foundation (BCRF), MEDIC Foundation, and 'Les Amis de l'Institut Bordet' (no grant numbers applicable). SJD received an Australian National Breast Cancer Foundation and Victorian Cancer Agency Early Career Fellowship (no grant numbers applicable).