Journal article
Analysis of circulating tumor DNA to monitor metastatic breast cancer
SJ Dawson, DWY Tsui, M Murtaza, H Biggs, OM Rueda, SF Chin, MJ Dunning, D Gale, T Forshew, B Mahler-Araujo, S Rajan, S Humphray, J Becq, D Halsall, M Wallis, D Bentley, C Caldas, N Rosenfeld
New England Journal of Medicine | Published : 2013
Abstract
BACKGROUND: The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively investigated or compared with other circulating biomarkers in breast cancer. METHODS: We compared the radiographic imaging of tumors with the assay of circulating tumor DNA, CA 15-3, and circulating tumor cells in 30 women with metastatic breast cancer who were receiving systemic therapy. We used targeted..
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Funding Acknowledgements
Supported by grants from Cancer Research UK, and the Experimental Cancer Medicine Centre and National Institute for Health Research Cambridge Biomedical Research Centre, and by an Australian National Health and Medical Research Council-R.G. Menzies Early Career Fellowship (to Dr. Dawson).