Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition
Stephanie M Tortorella, Simon G Royce, Paul V Licciardi, Tom C Karagiannis
Antioxidants & Redox Signaling | MARY ANN LIEBERT, INC | Published : 2015
SIGNIFICANCE: Sulforaphane, produced by the hydrolytic conversion of glucoraphanin after ingestion of cruciferous vegetables, particularly broccoli and broccoli sprouts, has been extensively studied due to its apparent health-promoting properties in disease and limited toxicity in normal tissue. Recent Studies: Recent identification of a sub-population of tumor cells with stem cell-like self-renewal capacity that may be responsible for relapse, metastasis, and resistance, as a potential target of the dietary compound, may be an important aspect of sulforaphane chemoprevention. Evidence also suggests that sulforaphane may target the epigenetic alterations observed in specific cancers, reversi..View full abstract
The support of the Australian Institute of Nuclear Science and Engineering (AINSE) is acknowledged. TCK was the recipient of AINSE awards. TCK was supported by an Australian Research Council Future Fellowship, and the Epigenomic Medicine Laboratory was supported by McCord Research. This study was supported in part by the Victorian Government's Operational Infrastructure Support Program.