Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents
Katherine Ververis, Alison Hiong, Tom C Karagiannis, Paul V Licciardi
BIOLOGICS-TARGETS & THERAPY | DOVE MEDICAL PRESS LTD | Published : 2013
Histone deacetylase (HDAC) inhibitors are an emerging class of therapeutics with potential as anticancer drugs. The rationale for developing HDAC inhibitors (and other chromatin-modifying agents) as anticancer therapies arose from the understanding that in addition to genetic mutations, epigenetic changes such as dysregulation of HDAC enzymes can alter phenotype and gene expression, disturb homeostasis, and contribute to neoplastic growth. The family of HDAC inhibitors is large and diverse. It includes a range of naturally occurring and synthetic compounds that differ in terms of structure, function, and specificity. HDAC inhibitors have multiple cell type-specific effects in vitro and in vi..View full abstract
The support of the Australian Institute of Nuclear Science and Engineering is acknowledged. TCK was the recipient of AINSE awards. The Epigenomic Medicine Laboratory is supported by the Australian Research Council Future Fellowship and McCord Research. The Allergy and Immune Disorders Laboratory is supported by MCRI, and PVL is the recipient of an Australian National Health and Medical Research Council training fellowship. Both laboratories are supported in part by the Victorian government's Operational Infrastructure Support Program.