Journal article

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5 Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche

Alistair J Langlands, Axel A Almet, Paul L Appleton, Ian P Newton, James M Osborne, Inke S Nathke

PLOS Biology | PUBLIC LIBRARY SCIENCE | Published : 2016

University of Melbourne Researchers


Awarded by Cancer Research UK

Awarded by Wellcome Trust

Awarded by ARC

Awarded by Engineering and Physical Sciences Research Council

Awarded by Medical Research Council

Funding Acknowledgements

Funding was provided by program grant C430/A11243 from Cancer Research UK ( to ISN supporting AJL, IPN, and PLA. Tissue imaging was also supported by a multiuser equipment grant from the Wellcome Trust ( (WT101468). AAA was partially supported by an ARC ( Discovery Project grant (DP110100795). JMO is supported by the University of Melbourne School of Mathematics and Statistics ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.We thank Prof. Laura Machesky (Beatson Institute) for providing tissue from Life-Act-GFP intestinal organoids. We are grateful for support from the Dundee Light Microscopy facility. We also thank Prof. Barry Hughes and Prof. Kerry Landman for valuable contributions to the mathematical modelling aspect of this work.