Journal article
Flicking the molecular switch underlying MLKL-mediated necroptosis
JM Hildebrand, IS Lucet, JM Murphy
Molecular and Cellular Oncology | TAYLOR & FRANCIS INC | Published : 2015
Open access
Abstract
The pseudokinase domain of the necroptosis effector mixed lineage kinase domain-like (MLKL) functions as a latch to restrain the unleashing of its N-terminal 4-helix bundle (4HB) domain. Cell death mediated by the 4HB domain relies on membrane association and oligomerization, which can be inhibited by an ATP-mimetic small molecule that binds the pseudokinase domain of MLKL.
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council fellowship to JMH, project 1057905 to JMM and ISL, and an Australian Research Council fellowship (FT100100100) to JMM. Additional support was obtained from the Australian Cancer Research Foundation, Victorian State Government Operational Infrastructure Support and NHMRC IRIISS grant (361646).