Polymer Capsules for Plaque-Targeted In Vivo Delivery
Joseph J Richardson, Mei Y Choy, Junling Guo, Kang Liang, Karen Alt, Yuan Ping, Jiwei Cui, Lok S Law, Christoph E Hagemeyer, Frank Caruso
ADVANCED MATERIALS | WILEY-V C H VERLAG GMBH | Published : 2016
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques.
Related Projects (2)
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
Awarded by National Health and Medical Research Council
Awarded by ARC
Awarded by National Heart Foundation
J.J.R. and M.Y.C. contributed equally to this work. The authors acknowledge Dr. Stephen Cody and Dr. Iska Carmichael from Monash Micro Imaging for confocal imaging, as well as Dr. Yung-Chih Chen (Baker IDI, Melbourne) for technical help. This research was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036) and by the National Health and Medical Research Council (project grant 1078118). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030) scheme and the National Heart Foundation under the Career Development Fellowship scheme (C.E.H., CR11M6066).