Journal article

Connectome sensitivity or specificity: which is more important?

Andrew Zalesky, Alex Fornito, Luca Cocchi, Leonardo L Gollo, Martijn P van den Heuvel, Michael Breakspear

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016

Abstract

Connectomes with high sensitivity and high specificity are unattainable with current axonal fiber reconstruction methods, particularly at the macro-scale afforded by magnetic resonance imaging. Tensor-guided deterministic tractography yields sparse connectomes that are incomplete and contain false negatives (FNs), whereas probabilistic methods steered by crossing-fiber models yield dense connectomes, often with low specificity due to false positives (FPs). Densely reconstructed probabilistic connectomes are typically thresholded to improve specificity at the cost of a reduction in sensitivity. What is the optimal tradeoff between connectome sensitivity and specificity? We show empirically an..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by Netherlands Organization for Scientific Research


Funding Acknowledgements

A.Z., A.F., L.C., L.L.H and M.B. are supported by the Australian National Health and Medical Research Council (grant identifiers: 1050504, 1066779, 1047648, 1037196, 1103252 and 1099082) and the Australian Research Council (ID: FT130100589, CE140100007). M.P.vdH. is supported by a VENI (451-12-001) grant from the Netherlands Organization for Scientific Research and a fellowship from MQ.