Response of human hair cortical cells to fractionated radiotherapy
CS Hamilton, CS Potten, JW Denham, PC OBrien, T Kron, P Ostwald, S Wright, J Ramsden
RADIOTHERAPY AND ONCOLOGY | ELSEVIER IRELAND LTD | Published : 1997
Hair cortical cell counting (HCCC) represents a non-invasive, in-vivo measure of cell kill in the human integument. Sixty-six patients undergoing conventionally fractionated, external beam radiotherapy for early stage carcinoma of the prostate had groin hair samples counted. This technique is a sensitive and reproducible measure of radiation effect and may have applicability as an in-vivo prediction tool or in the field of biological dosimetry. A repopulative follicular response occurring at 3-4 weeks may explain flattening of the dose response curve.